期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 23, 期 10, 页码 2027-2031出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-14-0020
关键词
-
资金
- Dana-Farber/Harvard Cancer Center Specialized Programs of Research Excellence (SPORE) in Prostate Cancer [P50CA090381-08]
- Prostate Cancer Foundation
- Swedish Research Council [2009-7309]
- Royal Physiographic Society in Lund, Sweden
- [NCICA136578]
- [CA141298]
- [CA097193]
- [PO1 CA055075]
- [UM1CA167552]
- [U01CA098233]
Background: The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation in AR exists, including a polymorphic CAG repeat sequence that is inversely associated with transcriptional activity. Experimental data suggest that heightened AR activity facilitates formation of TMPRSS2:ERG, a gene fusion present in approximately 50% of tumors of patients with prostate cancer. Methods: We undertook a nested case-control study to investigate the hypothesis that shorter CAG repeat length would be associated with prostate cancer risk defined by TMPRSS2: ERG status. The study included 291 men with prostate cancer (147 ERG-positive) and 1,221 cancer-free controls. ORs and 95% confidence intervals (CI) were calculated using logistic regression. Results: Median CAG repeat length (interquartile range) among controls was 22 (20-24). Men with shorter CAG repeats had an increased risk of ERG-positive (OR, 1.07 per 1 repeat decrease; 95% CI, 1.00-1.14), but not ERG-negative prostate cancer (OR, 0.99 per 1 repeat decrease; 95% CI, 0.93-1.05). Conclusions: These data suggest that shorter CAG repeats are specifically associated with development of TMPRSS2: ERG-positive prostate cancer. Impact: Our results provide supportive evidence that androgen signaling underlies the development of prostate tumors that harbor TMPRSS2: ERG. Moreover, these results suggest that TMPRSS2: ERG may represent a unique molecular subtype of prostate cancer with an etiology distinct from TMPRSS2: ERG-negative disease. (C) 2014 AACR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据