期刊
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
卷 12, 期 5, 页码 463-471出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10837450701556933
关键词
microparticles; polymer blend; pantoprazole; gastro; resistance; solvent evaporation
Microparticles of poly( epsilon- caprolactone) and of its blend with Eudragit (R) S100 were prepared by emulsion/ solvent evaporation technique to provide controlled release and gastro- resistance for an acid labile drug. This drug was sodium pantoprazole, a proton pump inhibitor. Both formulations were successfully prepared, but only the microparticles prepared with the blend were capable of stabilizing the drug in the acid medium. Furthermore, this formulation showed in vivo protection of stomachs against ulceration caused by ethanol in rats. These microparticles were tabletted, and the tablets demonstrated slower drug release and higher acid protection than the microparticles before tabletting.
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