期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 23, 期 4, 页码 575-583出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-13-1162
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资金
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
- NHLBI NIH HHS [HHSN268201100046C, HHSN268201100001I, HHSN268201100002I, HHSN268201100004I] Funding Source: Medline
- NIA NIH HHS [HHSN271201100004C] Funding Source: Medline
- WHI NIH HHS [HHSN268201100002C, HHSN268201100001C, HHSN268201100004C, HHSN268201100003C] Funding Source: Medline
Background: Few studies have evaluated whether adherence to dietary recommendations is associated with mortality among cancer survivors. In breast cancer survivors, we examined how postdiagnosis Healthy Eating Index (HEI)-2005 scores were associated with all-cause and cause-specific mortality. Methods: Our prospective cohort study included 2,317 postmenopausal women, ages 50 to 79 years, in the Women's Health Initiative's Dietary Modification Trial (n = 1,205) and Observational Study (n = 1,112), who were diagnosed with invasive breast cancer and completed a food frequency questionnaire after being diagnosed. We followed women from this assessment forward. We used Cox proportional hazards models to estimate multivariate-adjusted HRs and 95% confidence intervals (CI) for death from any cause, breast cancer, and causes other than breast cancer, according to HEI-2005 quintiles. Results: Over 9.6 years, 415 deaths occurred. After adjustment for key covariates, women consuming better quality diets had a 26% lower risk of death from any cause (HRQ4:Q1, 0.74; 95% CI, 0.55-0.99; P-trend = 0.043) and a 42% lower risk of death from non-breast cancer causes (HRQ4:Q1, 0.58; 95% CI, 0.38-0.87; P-trend = 0.011). HEI-2005 score was not associated with breast cancer death (HRQ4:Q1, 0.91; 95% CI, 0.60-1.40; P-trend = 0.627). In analyses stratified by tumor estrogen receptor (ER) status, better diet quality was associated with a reduced risk of all-cause mortality among women with ER+ tumors (n = 1,758; HRQ4:Q1, 0.55; 95% CI, 0.38-0.79; P-trend = 0.0009). Conclusion: Better postdiagnosis diet quality was associated with reduced risk of death, particularly from non-breast cancer causes. Impact: Breast cancer survivors may experience improved survival by adhering to U. S. dietary guidelines. (C) 2014 AACR.
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