期刊
CELLS TISSUES ORGANS
卷 185, 期 1-3, 页码 61-65出版社
KARGER
DOI: 10.1159/000101304
关键词
beta-catenin; ZO-1; vimentin; matrix metalloproteinase; epithelial-mesenchymal transition
The cytoplasmic/nuclear relocalization of beta-catenin and ZO-1 from the adherens and tight junctions are common processes of the epithelial-mesenchymal transition (EMT) associated with tumor invasion. Data are now accumulating to demonstrate that these molecules, which shuttle between the plasma membrane and the nucleus or the cytosol, are involved in signaling pathways, and contribute to the regulation of genes such as vimentin or matrix metalloproteinase-14 which are turned on during EMT. Copyright (c) 2007 S. Karger AG, Basel.
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