期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 22, 期 5, 页码 782-791出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-12-1399
关键词
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资金
- Gilead
- Bristol Myers Squibb
- Intercept
- National Cancer Institute/Center to Reduce Cancer Health Disparities
- National Institute on Minority Health and Health Disparities
- Office of the Dean, School of Medicine, University of California, Davis
- [P01 CA109091-01A1]
- [U54CA153499]
Background: Hepatitis B-linked liver cancer disproportionately affects Hmong Americans. With an incidence rate of 18.9 per 100,000, Hmong Americans experience liver cancer at a rate that is 6 to 7 times more than that of non-Hispanic Whites. Serologic testing for the hepatitis B virus (HBV) is a principal means to prevent liver cancer-related deaths through earlier identification of those at risk. Methods: Academic researchers and Hmong leaders collaborated in the design, conduct, and evaluation of a 5-year randomized controlled trial testing a lay health worker (LHW) intervention to promote HBV testing among 260 Hmong adults through in-home education and patient navigation. Results: Intervention group participants were more likely to report receiving serologic testing for HBV (24% vs. 10%, P = 0.0056) and showed a greater mean increase in knowledge score (1.3 vs. 0.3 points, P = 0.0003) than control group participants. Multivariable modeling indicated that self-reported test receipt was associated with intervention group assignment [OR 3.5; 95% confidence interval (CI) 1.3-9.2], improvement in knowledge score (OR 1.3 per point; 95% CI 1.02-1.7), female gender (OR 5.3; 95% CI 1.7-16.6), and having seen a doctor in the past year at baseline (OR 4.8; 95% CI 1.3-17.6). The most often cited reason for testing was a doctor's recommendation. Conclusions: LHWs were effective in bringing about HBV screening. Doctor visits and adherence to doctors' recommendations were pivotal. Participation of health care providers is essential to increase HBV testing. Impact: LHW scan significantly increase HBV screening rates for Hmong but their doctors' recommendation is highly influential and should be pursued. (c) 2013 AACR.
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