期刊
NEUROPSYCHOBIOLOGY
卷 55, 期 2, 页码 96-111出版社
KARGER
DOI: 10.1159/000104277
关键词
age; white matter; magnetic resonance imaging
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000071] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH060023, P50MH066392, R01MH056489] Funding Source: NIH RePORTER
- NCRR NIH HHS [M01 RR000071, M01 RR00071] Funding Source: Medline
- NIMH NIH HHS [MH56489, MH60023, R01 MH060023, R01 MH056489-02, P50 MH066392, R01 MH060023-01, P50 MH66392-01, P50 MH066392-01] Funding Source: Medline
We acquired diffusion tensor images on 33 normal adults aged 22-64 and 15 adolescents aged 14-21. We assessed relative anisotropy in stereotaxically located regions of interest in the internal capsule, corpus callosum, anterior thalamic radiations, frontal anterior fasciculus, fronto-occipital fasciculus, temporal lobe white matter, cingulum bundle, frontal inferior longitudinal fasciculus, frontal superior longitudinal fasciculus, and optic radiations. All of these structures except the optic radiations, corpus callosum, and frontal inferior longitudinal fasciculus exhibited differences in anisotropy between adolescents and adults. Areas with anisotropy increasing with age included the anterior limb of the internal capsule, superior levels of the frontal superior longitudinal fasciculus and the inferior portion of the temporal white matter. Areas with anisotropy decreasing with age included the posterior limb of the internal capsule, anterior thalamic radiations, fronto-occipital fasciculus, anterior portion of the frontal anterior fasciculus, inferior portion of the frontal superior longitudinal fasciculus, cingulum bundle and superior portion of the temporal axis. Sex differences were found in the majority of areas but were most marked in the cingulum bundle and internal capsule. These results suggest continuing white matter development between adolescence and adulthood. Copyright (c) 2007 S. Karger AG, Basel.
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