期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 22, 期 5, 页码 792-802出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-13-0054
关键词
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资金
- National Cancer Institute [R01 CA039742]
Background: The 2007 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines encourage cancer survivors to follow its cancer prevention recommendations. We evaluated whether adherence to the WCRF/AICR guidelines for cancer prevention was associated with lower mortality among older female cancer survivors. Methods: From 2004 to 2009, 2,017 participants in the Iowa Women's Health Study who had a confirmed cancer diagnosis (1986-2002) and completed the 2004 follow-up questionnaire were followed. Adherence scores for the WCRF/AICR guidelines for body weight, physical activity, and diet were computed assigning one, 0.5 or 0 points to each of eight recommendations depending on the degree of adherence. All-cause (n = 461), cancer-specific (n = 184), and cardiovascular disease (CVD)-specific mortality (n = 145) were compared by the total adherence score and by adherence scores for each of the three components of the recommendations. Results: Women with the highest (6-8) versus lowest (0-4) adherence score had lower all-cause mortality [HR = 0.67; 95% confidence of interval (CI), 0.50-0.94]. Meeting the physical activity recommendation was associated with lower all-cause (P-trend < 0.0001), cancer-specific (P-trend = 0.04), and CVD-specific mortality (P-trend = 0.03). Adherence to dietary recommendations was associated with lower all-cause mortality (P-trend < 0.05), whereas adherence to the body weight recommendation was associated with higher all-cause mortality (P-trend = 0.009). Conclusions: Adherence to the WCRF/AICR guidelines was associated with lower all-cause mortality among older female cancer survivors. Adherence to the physical activity recommendation had the strongest association with lower all-cause and disease-specific mortality. Impact: Older cancer survivors may decrease their risk of death by leading a healthy lifestyle after a cancer diagnosis. (c) 2013 AACR.
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