期刊
DRUG METABOLISM AND PHARMACOKINETICS
卷 22, 期 4, 页码 225-254出版社
JAPANESE SOC STUDY XENOBIOTICS
DOI: 10.2133/dmpk.22.225
关键词
solubility; dissolution; drug discovery; high throughput; simulation; preformulation
The purposes of the review are to: a) Provide a comprehensible introduction of the-state-of-the-art sciences of solubility and dissolution, b) introduce typical technologies to assess solubility and dissolution, and c) propose the best practice strategy. The theories of solubility and dissolution required in drug discovery were reviewed especially from the view point of oral absorption. The physiological conditions in the gastrointestinal fluid in humans and animals were then briefly summarized. Technologies to assess solubility and dissolution in drug discovery were then introduced. Recently, these technologies have been improved by the laboratory automation and computational technologies. Finally, the strategies to apply these technologies for a drug discovery project were discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据