期刊
CANCER DETECTION AND PREVENTION
卷 31, 期 6, 页码 436-442出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cdp.2007.10.016
关键词
vascular endothelial growth factor-C; vascular endothelial growth factor-D; pancreatic adenocarcinoma; lymphangiogenesis; angiogenesis; lymph node metastasis; intratumor an peritumoral vessel density; lymphatic vessel endothelial hyaluronan receptor-1; microlymphatic vessel density
类别
Background: We analyzed the intratumoral and peritumoral microvessel density (MVD) and microlymphatic vessel density (MLVD) in pancreatic adenocarcinoma (PAC) and recorded the expression of vascular endothelial growth factor (VEGF)-C and -D. These data were tested for their significance tor tumor progression. Methods: The tissue samples were obtained from 30 patients with PAC. The expression of VEGF-C and -D, MLVD,MVD was assayed by immunohistochemical staining. The expression of VEGF-A and -C, and -D mRNA was detected by semi-quantitative RT-PCR. Results: Immunohistochemical analysis revealed the presence of VEGF-C and -D immunoreactivity in 73%(22/30) and 57% (17/30). The positive rates of VEGF-C and -D protein in central portion of tumors (30% and 16.7%) were significantly lower than those in marginal portion (73.3% and 56.7%). The group with hi h expression of VEGF-C and -D in marginal portion had higher incidence of lymph node metastasis, lymphatic invasion and venous invasion. The MLVD in both of the VEGF-C and -D positive groups was higher than that in the negative groups, and the lymph node metastasis increased. MVD in the VEGF-C positive group was higher than that in the negative group. Conclusions: The expression of VEGF-C and -D in the marginal portion of tumor significantly associated with lymphatic metastasis and prognosis in patients with PAC and may induced lymphangiogenesis. VEGF-C was important in the regulation of angiogenesis and lymphangiogenesis in PAC. (C) 2007 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据