期刊
CELLS TISSUES ORGANS
卷 185, 期 1-3, 页码 157-161出版社
KARGER
DOI: 10.1159/000101316
关键词
microRNAs; gene expression regulation; transforming growth factor-beta 1; epithelial-mesenchymal transition; neoplasms
Noncoding microRNAs act as posttranscriptional repressors of gene function and are often deregulated in cancers and other diseases. Here we review recent findings on microRNA roles in tumorigenesis and report a microRNA profiling screen in transforming growth factor-beta 1 (TGF-beta)-induced epithelial-mesenchymal transition (EMT) in human keratinocytes, a model of epithelial cell plasticity underlying epidermal injury and skin carcinogenesis. We describe a novel EMT-specific microRNA signature that includes induction of miR-21, a candidate oncogenic microRNA associated with carcinogenesis. By integrating the microRNA screen results with target prediction algorithms and gene expression profiling data, we outline a framework for TGF-beta-directed microRNA: messenger RNA (mRNA) regulatory circuitry and discuss its biological relevance for tumor progression. Copyright (c) 2007 S. Karger AG, Basel.
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