期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 21, 期 7, 页码 1156-1166出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-12-0066
关键词
-
资金
- NHS
- National Health and Medical Research Council (NHMRC) [628911]
- NHMRC
- National Breast Cancer Foundation/Cancer Australia
- ELAN-Program of the University Hospital Erlangen (Erlangen, Germany)
- ELAN program of the University Hospital Erlangen
- Spain's Health Research Fund (Fond de Investigacio'n Sanitaria) [FIS PI060386]
- Collaboration Agreement between Astra-Zeneca [EPY 1306/06]
- Institut de Salud Carlos III
- Spanish Federation of Breast Cancer (FECMA)
- Europe against Cancer Programme of the European Commission (SANCO)
- Dutch Ministry of Health
- Dutch Cancer Society
- ZonMW the Netherlands Organisation for Health Research and Development
- World Cancer Research Fund (WCRF)
- Cancer Research UK [C11518/A5644, C5047/A5830]
- Medical Research Council
- Stroke Association
- British Heart Foundation
- UK Department of Health
- Research into Ageing and Academy of Medical Sciences
- National Cancer Institute, NIH (Bethesda, MD) [CA17054, CA74847]
- California Breast Cancer Research Program of the University of California [4PB-0092]
- National Institute of Environmental Health Sciences, NIH [N01-PC-35139, T32 ES-013678]
- UK Medical Research Council [G9600413]
- Mermaid arm of the Eve Appeal
- Public Health Service from the National Cancer institute, NIH, Department of Health and Human Services [P50 CA 116201, R01 CA 128931, R01 CA 128931-S01, R01 CA 122340, CA131332, CA087969, CA089393, CA049449, CA98233]
- Cancer Council of Victoria
- Victorian Breast Cancer Research Consortium
- National Cancer Institute [R37CA054281, R01CA063464, R01CA085265, R25CA090956, R01CA132839]
- Cancer Research UK
- Breast Cancer Campaign
- Norwegian Research Council [183621/S10, 175240/S10]
- Norwegian Cancer Society [175240/S10, PK80108002, PK60287003]
- Radium Hospital Foundation
- South Eastern Norway Regional Health Authority [S-02036]
- U.S. National Cancer Institute, NIH under REA (Cancer Care Ontario) [CA-06-503, U01 CA69467]
- Intramural Research Program of the U.S. National Cancer Institute, Department of Health and Human Services
- Norway through the Polish - Norwegian Research Fund [PNRE-243-AI-1/07]
- Marit and Hans Rausing's Initiative against Breast Cancer
- National Institutes of Health, Susan Komen Foundation
- Agency for Science, Technology and Research of Singapore (A*STAR)
- Cancer Research UK [14565, 15007, 10118, 11022, 14136] Funding Source: researchfish
- Medical Research Council [G1000143, G0401527, MC_U106179471] Funding Source: researchfish
- National Breast Cancer Foundation [PF-11-20] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10096] Funding Source: researchfish
Background: Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biologic mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to interindividual differences in mammographic density measures. Methods: We established an international consortium (DENSNP) of 19 studies from 10 countries, comprising 16,895 Caucasian women, to conduct a pooled cross-sectional analysis of common breast cancer susceptibility variants in 14 independent loci and mammographic density measures. Dense and nondense areas, and percent density, were measured using interactive-thresholding techniques. Mixed linear models were used to assess the association between genetic variants and the square roots of mammographic density measures adjusted for study, age, case status, BMI, and menopausal status. Results: Consistent with their breast cancer associations, the C-allele of rs3817198 in LSP1 was positively associated with both adjusted dense area (P = 0.00005) and adjusted percent density (P = 0.001), whereas the Aallele of rs10483813 in RAD51L1 was inversely associated with adjusted percent density (P = 0.003), but not with adjusted dense area (P = 0.07). Conclusion: We identified two common breast cancer susceptibility variants associated with mammographic measures of radiodense tissue in the breast gland. Impact: We examined the association of 14 established breast cancer susceptibility loci with mammographic density phenotypes within a large genetic consortium and identified two breast cancer susceptibility variants, LSP1-rs3817198 and RAD51L1-rs10483813, associated with mammographic measures and in the same direction as the breast cancer association. Cancer Epidemiol Biomarkers Prey; 21(7); 1156-66. (C)2012 AACR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据