期刊
FEMS MICROBIOLOGY REVIEWS
卷 31, 期 3, 页码 278-292出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2006.00062.x
关键词
mycothiol; detoxification; nitrosative stress; thiol; mycothiol amidase; antibiotic resistance
类别
资金
- NIGMS NIH HHS [S06 GM061223-05A1] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [S06GM061223] Funding Source: NIH RePORTER
The pseudodisaccharide mycothiol is present in millimolar levels as the dominant thiol in most species of Actinomycetales. The primary role of mycothiol is to maintain the intracellular redox homeostasis. As such, it acts as an electron acceptor/donor and serves as a cofactor in detoxification reactions for alkylating agents, free radicals and xenobiotics. In addition, like glutathione, mycothiol may be involved in catabolic processes with an essential role for growth on recalcitrant chemicals such as aromatic compounds. Following a little over a decade of research since the discovery of mycothiol in 1994, we summarize the current knowledge about the role of mycothiol as an enzyme cofactor and consider possible mycothiol-dependent enzymes.
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