期刊
COGNITIVE AND BEHAVIORAL NEUROLOGY
卷 20, 期 1, 页码 44-47出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNN.0b013e31802e5101
关键词
mild cognitive impairment; problem solving; dementia; visuospatial; memory; language; executive function; Alzheimer disease
资金
- NCRR NIH HHS [M01-RR-00034] Funding Source: Medline
- NIDA NIH HHS [DA15734] Funding Source: Medline
- NINDS NIH HHS [NS045222] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000034] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R21DA015734] Funding Source: NIH RePORTER
Background and Objective: It is important to determine which patients with mild cognitive impairment (MCI) are at risk for progression to dementia. The presence of mild impairments not restricted to the domain of memory may suggest such progression. Our goal is to determine how well a visuospatial problem solving task assessing the cumulative burden of frontal and posterior damage differentiates MCI patients from matched controls. Methods: Twenty-six patients with MCI [Clinical Dementia Rating (CDR) score of 0.5] and mini-mental state examination (MMSE) scores of at least 24/30, were compared with 20 age and education level matched controls without cognitive impairment. All patients were given the MMSE, Hopkins Verbal Learning Test (HVLT), Boston Naming Test (BNT), Rey Complex Figures copying (RCF), anagrams, and visuospatial problem solving battery (VPS). The VPS is a complex problem solving task, which we predicted would better discriminate patient groups than the relatively simpler tasks. Results: Differences existed between groups on most tasks, but logistic regression revealed that the VPS discriminated the 2 groups better than the other nonmemory cognitive tests. Conclusions: The VPS, a problem solving task assessing the cumulative burden of frontal and posterior damage is more sensitive for detecting nonmemory impairments in MCI than other tasks. Future research will be needed to determine if impairment in the VPS is a sensitive predictor of progression to dementia or treatment response.
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