期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 20, 期 10, 页码 2222-2231出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-11-0569
关键词
-
资金
- European Community [223175, HEALTH-F2-2009-223175]
- CR-UK [C1287/A10118, C1287/A12014]
- European Union COST [BM0606]
- Dutch Cancer Society [NKI 2001-2423, 2007-3839, DDHK 2004-3124, DDHK 2009-4318]
- Dutch National Genomics Initiative
- United States National Cancer Institute, NIH [RFA-CA-06-503]
- Breast Cancer Family Registry (BCFR)
- Cancer Care Ontario [U01 CA69467]
- Northern California Cancer Center [U01 CA69417]
- University of Melbourne [U01 CA69638]
- National Health and Medical Research Council of Australia
- New South Wales Cancer Council
- Victorian Health Promotion Foundation (Australia)
- Victorian Breast Cancer Research Consortium
- United States Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- Cancer Council of Tasmania
- Cancer Foundation of Western Australia
- NHMRC [199600, 145684, 288704, 454508]
- ELAN-Fond of the University Hospital of Erlangen
- Cancer Research UK [C1287/A10118, C8620/A8372, C8620/A8857, C490/A10124, C8197/A10123]
- Breakthrough Breast Cancer
- NHS
- Dietmar-Hopp Foundation
- Helmholtz Society
- German Cancer Research Center (DKFZ)
- Chief Physician Johan Boserup and Lise Boserup Fund
- Danish Medical Research Council
- Herlev Hospital
- Genome Spain Foundation
- Red Tematica de Investigacion Cooperativa en Cancer
- Asociacion Espanola Contra el Cancer
- Fondo de Investigacion Sanitario [PI081583, PI081120]
- Baden Wurttemberg Ministry of Science, Research and Arts
- German Cancer Aid (Deutsche Krebshilfe)
- US Military Acquisition (ACQ)Activity, Era of Hope Award [W81XWH-05-1-0204]
- Institute of Cancer Research (UK)
- Medical Research Council (UK)
- Deutsche Krebshilfe [107054]
- German Cancer Research Centre (DKFZ)
- Federal Ministry of Education and Research (BMBF) Germany [01KW9975/5, 01KW9976/8, 01KW9977/0, 01KW0114]
- Robert Bosch Foundation, Stuttgart
- Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany
- Deutsche Krebshilfe e. V. [70492, 70-2892-BR I]
- Hannover Medical School
- German Academic Exchange Program
- German Federal Ministry of Research and Education [RUS08/017]
- Kuopio University Hospital
- Cancer Fund of North Savo
- Finnish Cancer Organizations
- Academy of Finland
- University of Eastern Finland
- National Breast Cancer Foundation
- Queensland Cancer Fund
- Cancer Councils of New South Wales
- Cancer Councils of Victoria
- Cancer Councils of Tasmania
- Cancer Councils of South Australia
- Stichting tegen Kanker [232-2008, 196-2010]
- Hamburg Cancer Society
- German Cancer Research Center
- Ministero della Salute
- Ministero dell'Universita' e Ricerca [RBLAO3-BETH]
- Fondazione Italiana per la Ricerca sul Cancro
- Associazione Italiana per la Ricerca sul Cancro [4017]
- Fondazione IRCCS Istituto Nazionale Tumori [5 x 1000]
- NIH [CA122340, CA128978, CA87969, CA58860, CA92044]
- Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201]
- VicHealth
- Cancer Council Victoria
- Australian NHMRC [209057, 251553, 504711]
- Norwegian Research council [155218/V40, 175240/S10]
- Borrensen-Dale
- FUGE-NFR [181600/V11]
- Swizz Bridge Award
- Finnish Cancer Foundation
- Sigrid Juselius Foundation
- University of Oulu
- Oulu University Hospital
- National Cancer Institute, Department of Health and Human Services, USA
- Yorkshire Cancer Research
- Breast Cancer Campaign
- Ministry of Health and Welfare, Republic of Korea [AO30001]
- Polish Foundation of Science
- National Cancer Institute Thailand
- Institute of Biomedical Sciences, Academia Sinica, Taiwan
- Lon V Smith Foundation [LVS39420]
- NIHR Comprehensive Biomedical Research Centre
- Guy's & St. Thomas' NHS Foundation
- King's College London, United Kingdom
- Oxford Biomedical Research Centre
- [PBZ_KBN_122/P05/2004]
- MRC [G0700491] Funding Source: UKRI
- Cancer Research UK [11022, 10118] Funding Source: researchfish
- Cancer Research UK
- The Francis Crick Institute [10124] Funding Source: researchfish
- Medical Research Council [G0700491] Funding Source: researchfish
- National Institute for Health Research [03/DHCS/03/G121/51] Funding Source: researchfish
Background: The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium. Methods: Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness and histopathology were assessed using logistic regression. Results: For white Europeans, the per-allele OR associated with 5p12-rs10941679 was 1.11 (95% CI = 1.08-1.14, P = 7 x 10(-18)) for invasive breast cancer and 1.10 (95% CI = 1.01-1.21, P = 0.03) for DCIS. For Asian women, the estimated OR for invasive disease was similar (OR 1.07, 95% CI = 0.99-1.15, P = 0.09). Further analyses suggested that the association in white Europeans was largely limited to progesterone receptor (PR)positive disease (per-allele OR = 1.16, 95% CI = 1.12-1.20, P = 1 x 10(-18) vs. OR = 1.03, 95% CI = 0.99-1.07, P = 0.2 for PR-negative disease; P-heterogeneity 2 x 10(-7)); heterogeneity by ER status was not observed (P = 0.2) once PR status was accounted for. The association was also stronger for lower grade tumors [per-allele OR (95% CI) 1.20 (1.14-1.25), 1.13 (1.09-1.16), and 1.04 (0.99-1.08) for grade 1, 2, and 3/4, respectively; Ptrend 5 x 10(-7)]. Conclusion: 5p12 is a breast cancer susceptibility locus for PR-positive, lower grade breast cancer. Impact: Multicenter fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants. Cancer Epidemiol Biomarkers Prev; 20(10); 2222-31. (C) 2011 AACR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据