期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 19, 期 7, 页码 1822-1830出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-09-1317
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资金
- Alberta Cancer Research Institute [23905, 24258]
- Canadian Institutes of Health Research [MSH-87734]
- U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- Cancer Council Tasmania and Cancer Foundation of Western Australia
- National Health and Medical Research Council of Australia [199600]
- U.S. NIH [CA87538, CA112523, R01 CA 58598, N01-CN-55424, N01-PC-67001, RO1 CA 61107, R01 CA 122443, R01 CA 88868, P01 CA87969, R01 CA49449, T32 CA009001, U01 CA71966, R01 CA16056, U01 CA69417, CA14089, CA17054, CA61132, CA63464, N01-PC-67010, R03-CA113148]
- German Federal Ministry of Education and Research of Germany [01 GB 9401]
- Mermaid 1
- Danish Cancer Society
- Mayo Foundation
- California Cancer Research Program [00-01389V-20170, 2110200]
- California Department of Health Services [050-E8709]
- OAK Foundation
- Department of Health
- MRC [G0801875] Funding Source: UKRI
- Cancer Research UK [10118, 11022, 11021] Funding Source: researchfish
- Cancer Research UK
- The Francis Crick Institute [10119] Funding Source: researchfish
- Medical Research Council [G0801875] Funding Source: researchfish
- The Francis Crick Institute
- Cancer Research UK [10124] Funding Source: researchfish
Background: We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with risk of ovarian carcinoma overall and to use the large sample of assembled cases to investigate associations by histologic type. Methods: Associations were evaluated in the Ovarian Cancer Association Consortium, including 16 studies of 5,593 epithelial ovarian carcinoma cases and 9,962 controls of white non-Hispanic origin. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for age and study site. Results: The five polymorphisms were not associated with ovarian carcinoma overall (P-trend > 0.13); however, associations for the minor allele at TYMS rs495139 were observed for carcinomas of mucinous type (OR, 1.19; 95% CI, 1.03-1.39; P = 0.02), clear cell type (OR, 0.86; 95% CI, 0.75-0.99; P = 0.04), and endometrioid type (OR, 0.90; 95% CI, 0.81-0.99; P = 0.04; Pheterogeneity = 0.001). Restriction to low-grade mucinous carcinomas further strengthened the association for the mucinous type (OR, 1.32; 95% CI, 1.07-1.62; P = 0.01). TYMS rs495139 was not associated with serous type (OR, 1.06; 95% CI, 1.00-1.13; P = 0.05). Conclusions: TYMS rs495139 may be associated with a differential risk of ovarian carcinoma types, indicating the importance of accurate histopathologic classification. Impact: Biomarkers that distinguish ovarian carcinoma types are few, and TYMS rs495139 may provide a novel clue to type etiology. Cancer Epidemiol Biomarkers Prev; 19(7); 1822-30. (C) 2010 AACR.
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