期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 7, 期 1, 页码 55-73出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/187152007779314017
关键词
Platinum complexes; anticancer activity; mechanism of action; structure-activity relationships; synthesis; medicinal chemistry; accumulation; activation
资金
- FWF (Fonds zur Foerderung der wissenschaftlichen Forschung)
- Austrian Council for Research and Technology Development
- Faustus Forschung Translational Drug Development AG
- COST (European Co-operation in the Field of Scientific and Technical Research)
Cisplatin, carboplatin and oxaliplatin are anticancer drugs, which are efficiently used in the clinics all over the world. Besides a remarkable therapeutic efficacy in a series of solid tumors and outstanding activity of cisplatin against testicular germ-cell cancer, the platinum-based therapy is in part accompanied by a set of severe toxic side-effects. The design of platinum complexes being equipped with an exclusive selectivity for the tumoral tissue and exhibiting a lack of systemic toxicity ('magic bullets') is the great hope in the fight against cancer and also a motor within the expanding field of bioinorganic chemistry. In this review article, two promising strategies, namely accumulation and activation of tumor inhibiting platinum complexes specifically at the tumor site is presented, demonstrating a stepwise approach towards the 'magic bullet' concept propagated by Paul Ehrlich.
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