期刊
DEVELOPMENTAL NEUROSCIENCE
卷 29, 期 4-5, 页码 321-330出版社
KARGER
DOI: 10.1159/000105473
关键词
ischemia; neonatal brain injury; neonatal stroke; cell fate; stem cell; neurogenesis
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044025, P50NS035902] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS 35902, R01 NS044025, P50 NS035902] Funding Source: Medline
Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not been defined, and local changes in cell fate decision may play a role in functional improvement. We performed middle cerebral artery occlusion in P10 rats. EPO treatment (5 U/g IP) significantly preserved hemispheric brain volume 6 weeks after injury. Furthermore, EPO increased the percentage of newly generated neurons while decreasing newly generated astrocytes following brain injury, without demonstrating long-term differences in the subventricular zone. These results suggest that EPO may neuroprotect and direct cell fate toward neurogenesis and away from gliogenesis in neonatal stroke. Copyright c 2007 S. Karger AG, Basel.
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