期刊
HYPERTENSION IN PREGNANCY
卷 26, 期 4, 页码 463-471出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10641950701548414
关键词
N-terminal pro B-type natriuretic peptide; neonate; intrauterine growth restriction; fetus
Objective: To investigate changes in NT-proBNP in intrauterine-growth-restricted (IUGR) and appropriate-for-gestational-age (AGA) pregnancies. Methods: NT-proBNP levels were measured in 40 mothers (MS), umbilical cords (UC), and their 20 IUGR/20 AGA neonates on day 1 (NI) and day 4 (N4). Results: UC, N1, and N4 NT-proBNP was lower in IUGR pregnancies (p <= 0.049). In both groups, NT-proBNP levels were similar in MS and higher in N1 (p <= 0.001). In AGA, MS NT-proBNP correlated positively with UC. Conclusions: Fetal and neonatal NT-proBNP levels are lower in IUGR compared with AGA, probably due to blood flow redistribution in IUGR and NT-proBNP placental transport in AGA. NT-proBNP levels peak on N1.
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