期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 18, 期 11, 页码 2882-2886出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-09-0782
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资金
- Italian Association for Cancer Research (AIRC)
- Italian League Against Cancer
- Italian Ministry of Education
- Italian Foundation
- Cancer Research (FIRC)
Background: There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns. Methods: We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores. Results: We identified four major dietary patterns, named animal products, vitamins and fiber, vegetable unsaturated fatty acids, and starch-rich. We observed a positive association between gastric cancer risk and the animal products (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the starch-rich (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The vitamins and fiber pattern (OR, 0.60; 95% CI 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the vegetable unsaturated fatty acids pattern (OR, 0.89; 95% CI, 0.56-1.42). Conclusions: Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods. (Cancer Epidemiol Biomarkers Prev 2009;18(11): 2882-6)
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