期刊
MICROVASCULAR RESEARCH
卷 73, 期 1, 页码 58-73出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mvr.2006.07.001
关键词
positive pressure infusion; convection-enhanced delivery; interstitial flow; transvascular flow; mathematical modeling
A model of convection-enhanced delivery in brain and neoplastic tissue is presented that includes transvascular fluid exchange in addition to interstitial fluid transport. Measured values for the relevant material parameters are compiled from published literature. The transient distributions of interstitial fluid pressure and fluid velocity resulting from infusion into brain tissue and into a tissue-isolated tumor are derived, in addition to the steady-state distribution of interstitial fluid pressure and fluid velocity resulting from infusion into a tumor with a necrotic core. The analytic solutions suggest that (1) the distributions of both pressure and fluid velocity are very sensitive to the ratio of vascular conductivity and hydraulic conductivity; (2) in brain tissue, the convective fluid velocity is significant (within three orders of magnitude of the peak value, for example) for a large number of infusion catheter diameters away from the infusion site, whereas in neoplastic tissue the convective velocity is significant for a small number of infusion catheter diameters away from the infusion site; (3) the presence of a necrotic core substantially increases the convective fluid velocity in its vicinity; and (4) infusion proximal to a tumor is greatly impeded by the outward flow at the tumor's periphery. These and related findings are discussed in terms of their relevance to the treatment of tumors. (c) 2006 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据