期刊
CANCER EPIDEMIOLOGY
卷 34, 期 2, 页码 189-193出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.canep.2010.02.008
关键词
Oxaliplatin; Neurotoxicity; Colorectal cancer; GSTP1 Ile(105)Val; AGXT Pro(11)Leu; AGXT Ile(304)Met
资金
- Japan Society for the Promotion of Science [70432416]
- Grants-in-Aid for Scientific Research [19590533] Funding Source: KAKEN
Purpose: Although the risk of oxaliplatin-induced neuropathy depends on cumulative oxaliplatin dose, susceptibility to this adverse event differs greatly among patients. In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms: glutathione S-transferase pi (GSTP1) Ile(105)Val, and glyoxylate aminotransferase (AGXT) Pro(11)Leu and AGXT Ile(340)Met. Experimental design: Eighty-two Japanese patients with histologically confirmed colorectal cancer who received at least six cycles of the modified FOLFOX6 (m-FOLFOX6) regimen were enrolled. To minimize differences in cumulative oxaliplatin dose between patients, oxaliplatin-induced neuropathy was evaluated using an oxaliplatin-specific scale during the 2-week period after completion of the sixth cycle of treatment. Results: Forty-four patients developed grade 2/3 oxaliplatin-induced neuropathy. There were more patients carrying at least one GSTP1 (105)Val allele among the group with grade 2/3 neuropathy (18/44, 41%) than among the group with grade 1 neuropathy (9/38, 24%), although the difference was not statistically significant (P = 0.098). There were similar numbers of patients carrying at least one AGXT(105)Met allele in the grade 2/3 neuropathy (7/44, 16%) and grade 1 neuropathy groups (5/38, 13%; P = 0.725). The AGXT(11)Leu allele was not found in any of our patients or controls. Conclusions: We found no significant association between oxaliplatin-induced neuropathy and the GSTP1 Ile(105)Val and AGXT Ile(340)Met polymorphisms. Given that no AGXT(11)Leu allele was found among our study population (n = 177), evaluating this polymorphism in Japanese patients in future studies is likely to be uninformative. (C) 2010 Elsevier Ltd. All rights reserved.
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