期刊
PPAR RESEARCH
卷 2007, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2007/29275
关键词
-
资金
- EURON Graduate School of Neuroscience
The retinoid acid receptors (RAR) and peroxisome proliferator-activated receptors (PPAR) have been implicated in the regulation of inflammatory reactions. Both receptor families contain ligand-activated transcription factors which form heterodimers with retinoid X receptors (RXR). We review data that imply RAR/RXR and PPAR/RXR pathways in physiological reactions after spinal cord injury. Experiments show how RAR signaling may improve axonal regeneration and modulate reactions of glia cells. While anti-inflammatory properties of PPAR are well documented in the periphery, their possible roles in the central nervous system have only recently become evident. Due to its anti-inflammatory function this transcription factor family promises to be a useful target after spinal cord or brain lesions. Copyright (C) 2007 S. van Neerven and J. Mey.
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