期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 29, 期 1, 页码 71-80出版社
SPRINGER
DOI: 10.1007/s00281-007-0059-2
关键词
topical vaccination; skin immunity; stratum corneum; surfactants
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI067395] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01-AI067395-01] Funding Source: Medline
Skin is an ideal tissue for vaccine administration, as it is comprised of immunocompetent cells such as keratinocytes and Langerhans cells and elicits both innate and adaptive immune responses. In this paper, we summarize the immune responses induced by topical vaccination of the skin and review the effects of adjuvants on skin vaccination. We also summarize the existing techniques for skin vaccination. New techniques such as the use of lasers to enhance skin permeability are also discussed, as well as the role of the stratum corneum in skin vaccination. A recent study demonstrating enhanced skin vaccination by using surfactants to extract partial lamellar lipids of the stratum corneum will also be introduced in this review.
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