期刊
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
卷 12, 期 1, 页码 71-82出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10911-007-9039-3
关键词
breast cancer; collagen; fibronectin; matrix-turnover; metastasis
资金
- NATIONAL CANCER INSTITUTE [R01CA085944] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA85944] Funding Source: Medline
Breast cancer diagnosed after a completed pregnancy has higher metastatic potential and therefore a much poorer prognosis. We hypothesize that following pregnancy the process of mammary gland involution, which returns the gland to its pre-pregnant state, co-opts some of the programs of wound healing. The pro-inflammatory milieu that results, while physiologically normal, promotes tumor progression. In this review, the similarities between mammary gland involution after cessation of milk-production and pathological tissue remodeling are discussed in light of emerging data demonstrating a role for pathological tissue remodeling in cancer.
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