期刊
CANCER CHEMOTHERAPY AND PHARMACOLOGY
卷 71, 期 5, 页码 1309-1314出版社
SPRINGER
DOI: 10.1007/s00280-013-2130-0
关键词
Cisplatin; Gastric cancer; Neoadjuvant chemotherapy; Paclitaxel; Pathological response
资金
- Epidemiological & Clinical Research Information Network
- Grants-in-Aid for Scientific Research [25462038] Funding Source: KAKEN
Paclitaxel-cisplatin (TC) combination is effective and well tolerated in patients with unresectable gastric cancer. We investigated the efficacy and safety of TC for locally advanced gastric cancers in a neoadjuvant setting. Patients received 2-4 courses of paclitaxel (80 mg/m(2)) and cisplatin (25 mg/m(2)) on days 1, 8, and 15 in a 4-weekly schedule, followed by radical gastrectomy. Primary endpoint was the pathological response rate: percentage of tumors in which one-third or more parts were affected. All 52 patients enrolled were eligible. Thirty-six (69.7 %) patients completed two or more courses of chemotherapy. Forty-three patients (82.7 %) underwent surgery, 33 (63.5 %) had R0 resection, and there was no treatment-related death. The pathological response was 34.6 % (95 % CI 22.0-49.1) for all registered patients; the null hypothesis of tumor response a parts per thousand currency sign10 % was rejected (p < 0.0001). The 3-year overall survival was 41.5 % (95 % CI 27.4-55.0). The neoadjuvant chemotherapy with TC was safe and effective for patients with locally advanced gastric cancer, and further study is needed to confirm the effectiveness of this regimen.
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