期刊
CANCER CHEMOTHERAPY AND PHARMACOLOGY
卷 68, 期 4, 页码 1089-1092出版社
SPRINGER
DOI: 10.1007/s00280-011-1691-z
关键词
Non-small cell lung cancer; Epidermal growth factor receptor; Tyrosine kinase inhibitor; Erlotinib; Central nervous system metastasis; Cerebrospinal fluid
资金
- Grants-in-Aid for Scientific Research [23790597, 23390138] Funding Source: KAKEN
Purpose Recent reports indicate that refractory central nervous system (CNS) metastases of non-small cell lung cancer (NSCLC) are improved by high-dose gefitinib or erlotinib administration. Wedescribe a Japanese woman with NSCLC and CNS metastases who was resistant to 75 mg daily erlotinib, but the metastases were improved by 150 mg daily erlotinib. We investigated the plasma and CSF concentrations of erlotinib at each dose as well as the correlation between the plasma and CSF concentrations of erlotinib. Methods Including this patient, we administered 150 mg erlotinib daily to nine NSCLC patients with CNS metastases and measured the plasma and CSF concentrations just before administration on day 8. The concentrations were determined using high-performance liquid chromatography with ultraviolet detection. Results The plasma and CSF concentrations of erlotinib at a dose of 75 mg were 433 and 14 nM, respectively. The plasma and CSF concentrations of erlotinib at a dose of 150 mg were increased to 1,117 and 44 nM, respectively. The mean +/- standard deviation of CSF concentrations and penetration rates were 106 +/- 59 nM and 4.5 +/- 1.5%, respectively. There was a good correlation (R-2 = 0.84) between plasma and CSF concentrations (P = 0.0005). Conclusions This study indicates that CSF concentrations of erlotinib depend on its plasma concentration. As seen in this patient, high CSF concentrations of erlotinib can be achieved by high-dose administration, and this finding suggests the efficacy of high-dose administration, especially to refractory CNS metastases of NSCLC patients.
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