期刊
JOURNAL OF IMMUNOTOXICOLOGY
卷 4, 期 1, 页码 69-76出版社
INFORMA HEALTHCARE
DOI: 10.1080/15476910601154779
关键词
cytokine; Jak kinase; Stat protein; signal transduction
类别
Cytokines play pivotal roles in regulation of immune responses. Signaling proteins involved in cytokine signal transduction pathways can be potential targets of toxins causing aberrant immune responses. Binding of cytokines to their specific receptors induces activation of signal transduction pathways. In this review, an overview of the cytokine/cytokine receptor system, signaling pathways activated by cytokine receptors, their regulation mechanisms, pathological conditions caused by aberrant cytokine signaling, and issues to be elucidated in the near future is provided.
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