期刊
CANCER CHEMOTHERAPY AND PHARMACOLOGY
卷 68, 期 2, 页码 275-278出版社
SPRINGER
DOI: 10.1007/s00280-011-1683-z
关键词
Angiogenesis; Antiangiogenesis; Chemotherapy; Vascular normalization; VEGF
资金
- AIRC, Milan, Italy
It is well established that antibodies to vascular endothelial growth factor (VEGF) in combination with chemotherapeutic agents produce synergistic cytotoxicity in a range of cancer. In this review article, it has been analyzed whether the so-called vascular normalization of abnormal tumor blood vessels as an effect of VEGF inhibition in association with chemotherapeutic agents in the treatment of tumors produces a real benefit. Literature data show that the process of normalization of the structure of tumor blood vessels is not always accompanied with a real benefit. In fact as in the case of cerebral tumors, the process of normalization may induce a re-establishment of the low permeability characteristics of normal brain microvasculature, preventing the delivery of chemotherapeutics.
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