期刊
CANCER CHEMOTHERAPY AND PHARMACOLOGY
卷 64, 期 2, 页码 213-221出版社
SPRINGER
DOI: 10.1007/s00280-009-0991-z
关键词
Hydroxyurea; Hydroxamic acid derivatives; Cancer
资金
- Croatian Ministry of Science, Education and Sport's [098-0982464-2393]
- Foundation of Croatian Academy of Sciences and Arts
Hydroxyurea has been used for decades and it is still valuable for the treatment of some types of cancer. It inhibits ribonucleotide reductase (RNR) enzyme known to be crucial in the conversion of ribonucleotides into deoxyribonucleotides. However, nowadays the main focus has shifted to structurally similar hydroxamic acid derivatives that target specific enzymes involved in cancer progression such as histone deacetylases, matrix metalloproteinases and also RNR.
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