期刊
CANCER CELL INTERNATIONAL
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12935-018-0607-y
关键词
Galectin-1; Cancer; Prognosis; Meta-analysis
类别
资金
- Youth Medical Talent Project of Jiangsu Province [QNRC2016292]
- China Postdoctoral Science Foundation [63, 2018M632371]
- Natural Science Foundation of Jiangsu Province [BK20141161, BK20150251]
Background: The prognostic significance of galectin-1 (Gal-1) expression in cancerous patients has been assessed for several years while the results remain controversial. Thus, we performed the first comprehensive meta-analysis to evaluate the prognostic value of Gal-1 expression in cancerous patients. Methods: We searched Pubmed, Embase and Web of Science to recruit studies on the prognostic impact of Gal-1 expression in cancerous patients. Eighteen studies containing 2674 patients were involved in this meta-analysis until March 30, 2018. Pooled hazard ratios (HRs) with 95% confidence interval (95% CI) were calculated to estimate the effect using random-effects model. Results: The pooled results revealed that high Gal-1 expression in cancer tissue associated with a poor OS (HR = 1.79, 95% CI 1.54-2.08, P < 0.001). In the subgroup of tumor type, it's observed that high Gal-1 expression was significant correlated with poor OS in digestive cancers without heterogeneity (HR = 1.94, 95% CI 1.64-2.30, P < 0.001; fixedeffects model; -I-2 = 20.1%, P = 0.276). Conclusions: Our present meta-analysis indicates that high Gal-1 expression might be a predictive factor of poor prognosis in cancers, particularly in digestive cancers.
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