期刊
CANCER CELL
卷 26, 期 5, 页码 638-652出版社
CELL PRESS
DOI: 10.1016/j.ccell.2014.09.007
关键词
-
资金
- NIH [U01CA105379, U54 CA163123]
- Genentech
- Margaret A. Cunningham Immune Mechanisms in Cancer Research Fellowship
- ARCS
It is well understood that antigen-presenting cells (APCs) within tumors typically do not maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse tumor models and human tumor biopsies, we have delineated the intratumoral dendritic cell (DC) populations as distinct from macrophage populations. Within these, CD103(+) DCs are extremely sparse and yet remarkably capable CTL stimulators. These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FTL3L cytokines. Regressing tumors have higher proportions of these cells, T-cell-dependent immune clearance relies on them, and abundance of their transcripts in human tumors correlates with clinical outcome. This cell type presents opportunities for prognostic and therapeutic approaches across multiple cancer types.
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