期刊
ANNUAL REVIEW OF MEDICINE
卷 58, 期 -, 页码 221-237出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.med.58.070605.115320
关键词
Pseudomonas toxin; diphtheria toxin; monoclonal antibody; recombinant immunotoxin
资金
- NATIONAL CANCER INSTITUTE [Z01BC010301, ZIABC008753, ZIABC010301, Z01BC008753, ZIABC010816, Z01BC010816] Funding Source: NIH RePORTER
Immunotoxms are proteins used to treat cancer that are composed of an antibody fragment linked to a toxin. The immunotoxin binds to a surface antigen on a cancer cell, enters the cell by endocytosis, and kills it. The most potent immunotoxins are made from bacterial and plant toxins. Refinements over many years have produced recombinant immunotoxins; these therapeutic proteins are made using protein engineering. Individual immunotoxins are designed to treat specific cancers. To date, most success has been achieved treating hematologic tumors. Obstacles to successful treatment of solid tumors include poor penetration into tumor masses and the immune response to the toxin component of the immunotoxin, which limits the number of cycles that can be given. Strategies to overcome these limitations are being pursued.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据