期刊
CANCER CELL
卷 25, 期 5, 页码 563-573出版社
CELL PRESS
DOI: 10.1016/j.ccr.2014.03.015
关键词
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资金
- British Lung Foundation
- Cancer Research UK via the Cambridge Cancer Centre
- British Lung Foundation [APHD11-4] Funding Source: researchfish
- Medical Research Council [G0601840, G1002610] Funding Source: researchfish
- MRC [G0601840, G1002610] Funding Source: UKRI
The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival. In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets.
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