期刊
CANCER CELL
卷 24, 期 5, 页码 673-685出版社
CELL PRESS
DOI: 10.1016/j.ccr.2013.09.010
关键词
-
资金
- Centre National de la Recherche Scientifique (CNRS)
- Aix Marseille Universite
- Agence Nationale de la Recherche [ANR-06JCJC-0094-01]
- Institut National du Cancer (INCa) [PL06-015, PLBI011-074 PACA-MANN]
- Association pour la Recherche sur le Cancer
- Fondation NRJ-Institut de France
- Institut Universitake de France
- Region PACA
- La Ligue Contre le Cancer (Label Ligue)
- Institut Paoli-Calmettes
- INCa
- Canceropole PACA
- French Ministry of Health
- Netris Pharma
The semaphorin guidance molecules and their receptors, the plexins, are often inappropriately expressed in cancers. However, the signaling processes mediated by plexins in tumor cells are still poorly understood. Here, we demonstrate that the Semaphorin 3E (Sema3E) regulates tumor cell survival by suppressing an apoptotic pathway triggered by the Plexin D1 dependence receptor. In mouse models of breast cancer, a ligand trap that sequesters Sema3E inhibited tumor growth and reduced metastasis through a selective tumor cytocidal effect. We further showed that Plexin D1 triggers apoptosis via interaction with the orphan nuclear receptor NR4A1. These results define a critical role of Sema3E/Plexin D1 interaction in tumor resistance to apoptosis and suggest a therapeutic approach based on activation of a dependence receptor pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据