期刊
CANCER CELL
卷 24, 期 4, 页码 450-465出版社
CELL PRESS
DOI: 10.1016/j.ccr.2013.08.020
关键词
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资金
- National Institutes of Health, National Cancer Institute
- Bay Area Breast Cancer SPORE [P50 CA 58207]
- Prospect Creek Foundation
- Durra Family Fund
- Mount Zion Health Fund
- Supporting Foundation of the Jewish Community Federation
- [U54 CA 112970]
- Medical Research Council [MC_UP_1202/4] Funding Source: researchfish
- MRC [MC_UP_1202/4] Funding Source: UKRI
A handful of tumor-derived cell lines form the mainstay of cancer therapeutic development, yielding drugs with an impact typically measured as months to disease progression. To develop more effective breast cancer therapeutics and more readily understand their clinical impact, we constructed a functional metabolic portrait of 46 independently derived breast cell lines. Our analysis of glutamine uptake and dependence identified a subset of triple-negative samples that are glutamine auxotrophs. Ambient glutamine indirectly supports environmental cystine acquisition via the xCT antiporter, which is expressed on one-third of triple-negative tumors in vivo. xCT inhibition with the clinically approved anti-inflammatory sulfasalazine decreases tumor growth, revealing a therapeutic target in breast tumors of poorest prognosis and a lead compound for rapid, effective drug development.
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