期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 8, 期 4, 页码 269-272出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622970701216673
关键词
panic attack; panic disorder; fMRI; amygdala
类别
Previous studies on neuronal activation correlates of panic attacks were mostly based on challenge tests, sensory-related stimulation or fear conditioning in healthy subjects. In the present study, we report on a female patient with panic disorder experiencing a spontaneous panic attack under an auditory habituation paradigm in the last stimulation block with sine tones captured with fMRI at 3T. The panic attack was associated with a significantly increased activity in the right amygdala. This is the first report on neuronal activation correlates of a spontaneous panic attack in a patient with panic disorder as measured by fMRI, which lends further support to a pivotal role of the amygdala in the pathogenesis of the disease.
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