期刊
CANCER CELL
卷 23, 期 1, 页码 48-62出版社
CELL PRESS
DOI: 10.1016/j.ccr.2012.12.001
关键词
-
资金
- National Cancer Institute [R01CA115399, R01CA152105, R21CA143887]
- MMRF
- leukemia lymphoma society TRP
- School of Medicine and Huntsman Cancer Institute of the University of Utah
Using sequential gene expression profiling (GEP) samples, we defined a major functional group related to drug resistance that contains chromosomal instability (CIN) genes. One CIN gene in particular, NEK2, was highly correlated with drug resistance, rapid relapse, and poor outcome in multiple cancers. Overexpressing NEK2 in cancer cells resulted in enhanced CIN, cell proliferation and drug resistance, while targeting NEK2 by NEK2 shRNA overcame cancer cell drug resistance and induced apoptosis in vitro and in a xenograft nnyeloma mouse model. High expression of NEK2 induced drug resistance mainly through activation of the efflux pumps. Thus, NEK2 represents a strong predictor for drug resistance and poor prognosis in cancer and could be an important target for cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据