期刊
CANCER CELL
卷 23, 期 1, 页码 1-3出版社
CELL PRESS
DOI: 10.1016/j.ccr.2012.12.018
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资金
- NCI NIH HHS [R01 CA043318] Funding Source: Medline
- NIEHS NIH HHS [R01 ES011858] Funding Source: Medline
Recent studies have highlighted large genomic regions prone to undergo epigenetic changes in cancers. In this issue of Cancer Cell, Bert and colleagues describe novel genomic domains with aberrant epigenetic changes involving concordant activation of neighboring genes. These domains involve aberrant CpG-island hypermethylation similar to that observed in gene silencing.
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