期刊
CANCER CELL
卷 21, 期 6, 页码 848-855出版社
CELL PRESS
DOI: 10.1016/j.ccr.2012.04.037
关键词
-
资金
- Fannie and John Hertz Foundation
- Leukemia and Lymphoma Society [5198-09]
- NIH [RO1-CA133404]
- NCI [PO1-CA42063]
- NCI Cancer Center [P30-CA14051]
MicroRNAs are a class of short similar to 22 nucleotide RNAs predicted to regulate nearly half of all protein coding genes, including many involved in basal cellular processes and organismal development. Although a global reduction in miRNAs is commonly observed in various human tumors, complete loss has not been documented, suggesting an essential function for miRNAs in tumorigenesis. Here we present the finding that transformed or immortalized Dicer1 null somatic cells can be isolated readily in vitro, maintain the characteristics of DICER1-expressing controls and remain stably proliferative. Furthermore, Dicer1 null cells from a sarcoma cell line, though depleted of miRNAs, are competent for tumor formation. Hence, miRNA levels in cancer may be maintained in vivo by a complex stabilizing selection in the intratumoral environment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据