期刊
CANCER CELL
卷 20, 期 2, 页码 143-157出版社
CELL PRESS
DOI: 10.1016/j.ccr.2011.07.007
关键词
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资金
- Sander-Stiftung
- Tour der Hoffnung
- Fritz-Lambert Preis
- Canadian Institutes of Health Research (CIHR)
- Pediatric Brain Tumor Foundation
- C.R. Younger Foundation
Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochennical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymonna tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.
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