SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-alpha stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype.