期刊
CANCER CELL
卷 20, 期 4, 页码 418-420出版社
CELL PRESS
DOI: 10.1016/j.ccr.2011.10.005
关键词
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资金
- NCI NIH HHS [R01 CA129387-05, R01 CA129387] Funding Source: Medline
Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells.
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