期刊
CANCER CELL
卷 18, 期 2, 页码 122-134出版社
CELL PRESS
DOI: 10.1016/j.ccr.2010.05.027
关键词
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资金
- Italian Association for Cancer Research (AIRC)
- Minister della Santa
- Alleanza Contro il Cancro
- MIUR-FIRB Italy
- European Community (EC)
- Telethon-Italy [GGP07177]
- Minister della Sanita
- Paul Blumel Stiftung fur medizinische Forschung
- F I R C
Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo. Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53.
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