期刊
CANCER CELL
卷 17, 期 6, 页码 597-608出版社
CELL PRESS
DOI: 10.1016/j.ccr.2010.04.024
关键词
-
资金
- American-Italian Cancer Foundation
- ASH Fellow Scholar Award
- PHS [T32 CA09151, CA116606]
- Children's Health Initiative of the Packard Foundation
- Leukemia and Lymphoma Society
- Williams Lawrence Foundation
- Stanford Cancer Center
Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据