期刊
CANCER CELL
卷 18, 期 4, 页码 303-315出版社
CELL PRESS
DOI: 10.1016/j.ccr.2010.09.007
关键词
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资金
- Dr. Josef Steiner Cancer Research Foundation
- University of Texas M.D. Anderson Research Trust
- NIH [1R01CA135444]
- [PI08-1345]
- [MEC09-05]
- ICREA Funding Source: Custom
The global impairment of mature microRNAs (miRNAs) is emerging as a common feature of human tumors. One interesting scenario is that defects in the nuclear export of precursor miRNAs (pre-miRNAs) might occur in transformed cells. Exportin 5 (XPO5) mediates pre-miRNA nuclear export and herein we demonstrate the presence of XPO5-inactivating mutations in a subset of human tumors with microsatellite instability. The XPO5 genetic defect traps pre-miRNAs in the nucleus, reduces miRNA processing, and diminishes miRNA-target inhibition. The XPO5 mutant form lacks a C-terminal region that contributes to the formation of the pre-miRNA/XPO5/Ran-GTP ternary complex and pre-miRNAs accumulate in the nucleus. Most importantly, the restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features.
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