期刊
CANCER CELL
卷 18, 期 5, 页码 510-523出版社
CELL PRESS
DOI: 10.1016/j.ccr.2010.10.012
关键词
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资金
- Howard Hughes Medical Institute
- Allen H. Blondy Research Fellowship
- Lewis and Lillian Becker
- UM-Comprehensive Cancer NIH [CA46592]
- European Commission
- Australian National Heath and Medical Research Council
- Human Frontiers Science Program
- Australia Post
We investigated whether melanoma is hierarchically organized into phenotypically distinct subpopulations of tumorigenic and nontumorigenic cells or whether most melanoma cells retain tumorigenic capacity, irrespective of their phenotype. We found 28% of single melanoma cells obtained directly from patients formed tumors in NOD/SCID IL2R gamma(null) mice. All stage II, III, and IV melanomas obtained directly from patients had common tumorigenic cells. All tumorigenic cells appeared to have unlimited tumorigenic capacity on serial transplantation. We were unable to find any large subpopulation of melanoma cells that lacked tumorigenic potential. None of 22 heterogeneously expressed markers, including CD271 and ABCB5, enriched tumorigenic cells. Some melanomas metastasized in mice, irrespective of whether they arose from CD271(-) or CD271(+) cells. Many markers appeared to be reversibly expressed by tumorigenic melanoma cells.
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