期刊
CANCER CELL
卷 18, 期 6, 页码 669-682出版社
CELL PRESS
DOI: 10.1016/j.ccr.2010.10.033
关键词
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资金
- Swedish Society for Medical Research
- Swedish Medical Research Council
- Hjarnfonden
- Sandler Post-doctoral Fellowship
- Joel A. Gingras Jr/American Brain Tumor Association
- Sandler Opportunity Award
- Farber Foundation
- National Brain Tumor Society
- NIH [CA097257]
- Children's Brain Tumor Foundation
- UCSF Academic Senate
- Pediatric Brain Tumor Foundation
- Alex's Lemonade Stand Foundation
- Samuel Waxman Cancer Research Foundation
- Accelerate Brain Cancer Cure
- Burroughs Wellcome Fund
Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.
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