期刊
CANCER CELL
卷 15, 期 4, 页码 315-327出版社
CELL PRESS
DOI: 10.1016/j.ccr.2009.02.011
关键词
-
资金
- Spanish Government (ISCIII) [PI040766, P1070648]
- Association for International Cancer [06-349]
- European Research Council [205819]
- European Commission Marie Curie International Reintegration [MIRG-CT-2005-017121]
- European Research Council (ERC) [205819] Funding Source: European Research Council (ERC)
- ICREA Funding Source: Custom
Glioma-initiating cells (GICs) are responsible for the initiation and recurrence of gliomas. Here, we identify a molecular mechanism that regulates the self-renewal capacity of patient-derived GICs. We show that TGF-beta and LIF induce the self-renewal capacity and prevent the differentiation of GICs. TGF-beta induces the self-renewal capacity of GICs, but not of normal human neuroprogenitors, through the Smad-dependent induction of LIF and the subsequent activation of the JAK-STAT pathway. The effect of TGF-beta and LIF on GICs promotes oncogenesis in vivo. Some human gliomas express high levels of LIF that correlate with high expression of TGF-beta 2 and neuroprogenitor cell markers. Our results show that TGF-beta and LIF have an essential role in the regulation of GICs in human glioblastoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据