期刊
CANCER CELL
卷 15, 期 6, 页码 539-550出版社
CELL PRESS
DOI: 10.1016/j.ccr.2009.03.027
关键词
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资金
- DOD Breast Cancer Research Program [DAMD17-03-1-0409]
- National Institute of Health [CA82716, CA646021, CA099031]
- Breast Cancer Research Foundation [CA94118]
- LPATH Biotechnologies
- National Institute of Health Core [P30 CA016672]
- Lpath Therapeutics, Inc
Lysophosphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.
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