期刊
CANCER CELL
卷 13, 期 3, 页码 221-234出版社
CELL PRESS
DOI: 10.1016/j.ccr.2008.01.031
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资金
- NCI NIH HHS [R01 CA105412, K01 CA120711] Funding Source: Medline
- NHLBI NIH HHS [R01 HL068648-04, R01 HL068648, R01 HL068648-03, R01 HL068648-05] Funding Source: Medline
In vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo assays and intravital imaging, we assessed the impact of cell migration, regulated by the integrin-associated tetraspanin CD151, on spontaneous human tumor cell metastasis. We demonstrate that promoting immobility through a CD151-specific metastasis blocking mAb prevents tumor cell dissemination by inhibiting intravasation without affecting primary tumor growth, tumor cell arrest, extravasation, or growth at the secondary site. In vivo, this loss of migration is the result of enhanced tumor cell-matrix interactions, promoted by CD151, which prevent dissociation by individual cells and leads to a subsequent inhibition of invasion and intravasation at the site of the primary tumor.
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